CATH Domain 4j5sD00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.220	Leucine Aminopeptidase, subunit E; domain 1
	3.40.220.10	Leucine Aminopeptidase, subunit E, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Aminopeptidase, subunit E, domain 1
Functional Family	O-acetyl-ADP-ribose deacetylase 1

Enzyme Information

3.5.1.-	In linear amides. based on mapping to UniProt Q9Y530
3.2.2.-	Hydrolyzing N-glycosyl compounds. based on mapping to UniProt Q9Y530

UniProtKB Entries (1)

OARD1_HUMAN

Homo sapiens

ADP-ribose glycohydrolase OARD1

PDB Structure

PDB	4J5S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Sharifi, R., Morra, R., Appel, C.D., Tallis, M., Chioza, B., Jankevicius, G., Simpson, M.A., Matic, I., Ozkan, E., Golia, B., Schellenberg, M.J., Weston, R., Williams, J.G., Rossi, M.N., Galehdari, H., Krahn, J., Wan, A., Trembath, R.C., Crosby, A.H., Ahel, D., Hay, R., Ladurner, A.G., Timinszky, G., Williams, R.S., Ahel, I. Embo J.