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1 keywords

CATH Domain 4ijqD00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

P00492
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 4IJQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity
Keough, D.T., Spacek, P., Hockova, D., Tichy, T., Vrbkova, S., Slavetinska, L., Janeba, Z., Naesens, L., Edstein, M.D., Chavchich, M., Wang, T.H., Jersey, J., Guddat, L.W.
J.Med.Chem.
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