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1 keywords

CATH Domain 4i0pD02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.40 Immunoglobulin-like
Homologous Superfamily 2.60.40.10 Immunoglobulins

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family HLA class II histocompatibility antigen, DRB1-1 beta chain

Enzyme Information

UniProtKB Entries (1)

P06340
DOA_HUMAN
Homo sapiens
HLA class II histocompatibility antigen, DO alpha chain

PDB Structure

PDB 4I0P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Guce, A.I., Mortimer, S.E., Yoon, T., Painter, C.A., Jiang, W., Mellins, E.D., Stern, L.J.
Nat.Struct.Mol.Biol.
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