CATH Domain 4hwtA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family	Threonine--tRNA ligase 2, cytoplasmic

Enzyme Information

6.1.1.3

Threonine--tRNA ligase.

based on mapping to UniProt P26639

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

UniProtKB Entries (1)

SYTC_HUMAN

Homo sapiens

Threonine--tRNA ligase, cytoplasmic

PDB Structure

PDB	4HWT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. Teng, M., Hilgers, M.T., Cunningham, M.L., Borchardt, A., Locke, J.B., Abraham, S., Haley, G., Kwan, B.P., Hall, C., Hough, G.W., Shaw, K.J., Finn, J. J.Med.Chem.