CATH Domain 4h4fA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Chymotrypsin-like elastase family member 1

Enzyme Information

3.4.21.2

Chymotrypsin C.

based on mapping to UniProt Q99895

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

-!- Reacts more readily with Tos-Leu-CH(2)Cl than Tos-Phe-CH(2)Cl, in contrast to chymotrypsin. -!- Belongs to peptidase family S1.

UniProtKB Entries (2)

Q99895	CTRC_HUMAN Homo sapiens Chymotrypsin-C
P01051	ICIC_HIRME Hirudo medicinalis Eglin C

PDB Structure

PDB	4H4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation. Batra, J., Szabo, A., Caulfield, T.R., Soares, A.S., Sahin-Toth, M., Radisky, E.S. J.Biol.Chem.