CATH Domain 4h12A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9BYW2
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9BYW2 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SETD2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SETD2

PDB Structure

PDB	4H12
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. Zheng, W., Ibanez, G., Wu, H., Blum, G., Zeng, H., Dong, A., Li, F., Hajian, T., Allali-Hassani, A., Amaya, M.F., Siarheyeva, A., Yu, W., Brown, P.J., Schapira, M., Vedadi, M., Min, J., Luo, M. J.Am.Chem.Soc.