CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt Q9NTG7
|
UniProtKB Entries (1)
| Q9NUB1 |
ACS2L_HUMAN
Homo sapiens
Acetyl-coenzyme A synthetase 2-like, mitochondrial
|
PDB Structure
| PDB | 4BVG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
Proc. Natl. Acad. Sci. U.S.A.
|
