CATH Domain 3vmlA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.718	Isopropylmalate Dehydrogenase
	3.40.718.10	Isopropylmalate Dehydrogenase

Domain Context

CATH Clusters

Superfamily	Isopropylmalate Dehydrogenase
Functional Family	3-isopropylmalate dehydrogenase

Enzyme Information

1.1.1.85

3-isopropylmalate dehydrogenase.

based on mapping to UniProt Q8E9N3

(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.

UniProtKB Entries (2)

D2YZL2	D2YZL2_9GAMM Shewanella benthica 3-isopropylmalate dehydrogenase
Q8E9N3	LEU3_SHEON Shewanella oneidensis MR-1 3-isopropylmalate dehydrogenase

PDB Structure

PDB	3VML
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure analysis of chimeric 3-isopropylmalate dehydrogenase between the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Hamajima, Y., Nagae, T., Watanabe, N., Kato, C. To be Published