CATH Domain 3ulkA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	Ketol-acid reductoisomerase (NADP(+))

Enzyme Information

1.1.1.86

Ketol-acid reductoisomerase (NADP(+)).

based on mapping to UniProt P05793

(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.

-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

P05793

ILVC_ECOLI

Escherichia coli K-12

Ketol-acid reductoisomerase (NADP(+))

PDB Structure

PDB	3ULK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle Wong, S.H., Lonhienne, T.G.A., Winzor, D.J., Schenk, G., Guddat, L.W. J.Mol.Biol.

Network disruptions