CATH Domain 3u7gA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Bifunctional polynucleotide phosphatase/kinase

Enzyme Information

2.7.1.78	Polynucleotide 5'-hydroxyl-kinase. based on mapping to UniProt Q9JLV6 ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. -!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
3.1.3.32	Polynucleotide 3'-phosphatase. based on mapping to UniProt Q9JLV6 A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate. -!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.

UniProtKB Entries (1)

PNKP_MOUSE

Mus musculus

Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB	3U7G
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates. Coquelle, N., Havali-Shahriari, Z., Bernstein, N., Green, R., Glover, J.N. Proc.Natl.Acad.Sci.USA