CATH Domain 3tg5A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.10	Tetratricopeptide repeat domain

Domain Context

CATH Clusters

Superfamily	Tetratricopeptide repeat domain
Functional Family	N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NRG4
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NRG4 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

P53_HUMAN

Homo sapiens

Cellular tumor antigen p53

PDB Structure

PDB	3TG5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation Wang, L., Li, L., Zhang, H., Luo, X., Dai, J., Zhou, S., Gu, J., Zhu, J., Atadja, P., Lu, C., Li, E., Zhao, K. J.Biol.Chem.