CATH Domain 3sffA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.800	Arginase; Chain A
	3.40.800.20	Histone deacetylase domain

Domain Context

CATH Clusters

Superfamily	Histone deacetylase domain
Functional Family	Histone deacetylase 8

Enzyme Information

3.5.1.98

Histone deacetylase.

based on mapping to UniProt Q9BY41

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9BY41

HDAC8_HUMAN

Homo sapiens

Histone deacetylase 8

PDB Structure

PDB	3SFF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Whitehead, L., Dobler, M.R., Radetich, B., Zhu, Y., Atadja, P.W., Claiborne, T., Grob, J.E., McRiner, A., Pancost, M.R., Patnaik, A., Shao, W., Shultz, M., Tichkule, R., Tommasi, R.A., Vash, B., Wang, P., Stams, T. Bioorg.Med.Chem.