CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Venom plasminogen activator TSV-PA |
Enzyme Information
| 3.4.21.95 |
Snake venom factor V activator.
based on mapping to UniProt P18965
Fully activates human clotting factor V by a single cleavage at the 1545- Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2).
-!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (2)
| P18965 |
VSPG_DABSI
Daboia siamensis
Factor V activator RVV-V gamma
|
| P12259 |
FA5_HUMAN
Homo sapiens
Coagulation factor V
|
PDB Structure
| PDB | 3S9C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of coagulation factor V recognition for cleavage by RVV-V
Febs Lett.
|
