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1 keywords

CATH Domain 3q7dB01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.25 Laminin
Homologous Superfamily 2.10.25.10 Laminin

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 3Q7D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Duggan, K.C., Hermanson, D.J., Musee, J., Prusakiewicz, J.J., Scheib, J.L., Carter, B.D., Banerjee, S., Oates, J.A., Marnett, L.J.
Nat.Chem.Biol.
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