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1 keywords

CATH Domain 3oofA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.565 Retinoid X Receptor
Homologous Superfamily 1.10.565.10 Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily Retinoid X Receptor
Functional Family Bile acid receptor isoform 4

Enzyme Information

UniProtKB Entries (1)

Q96RI1
NR1H4_HUMAN
Homo sapiens
Bile acid receptor

PDB Structure

PDB 3OOF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Richter, H.G.F., Benson, G.M., Bleicher, K.H., Blum, D., Chaput, E., Clemann, N., Feng, S., Gardes, C., Grether, U., Hartman, P., Kuhn, B., Martin, R.E., Plancher, J.M., Rudolph, M.G., Schuler, F., Taylor, S.
Bioorg.Med.Chem.Lett.
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