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1 keywords

CATH Domain 3obtA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.200  

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P19321
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P19321
BXD_CBDP
Clostridium botulinum D phage
Botulinum neurotoxin type D

PDB Structure

PDB 3OBT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Strotmeier, J., Lee, K., Volker, A.K., Mahrhold, S., Zong, Y., Zeiser, J., Zhou, J., Pich, A., Bigalke, H., Binz, T., Rummel, A., Jin, R.
Biochem.J.
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