CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1480 | Adenosylhomocysteinase-like |
Domain Context
CATH Clusters
| Superfamily | Adenosylhomocysteinase-like |
| Functional Family | Adenosylhomocysteinase |
Enzyme Information
| 3.3.1.1 |
Adenosylhomocysteinase.
based on mapping to UniProt P23526
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.
|
UniProtKB Entries (1)
| P23526 |
SAHH_HUMAN
Homo sapiens
Adenosylhomocysteinase
|
PDB Structure
| PDB | 3NJ4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.
J.Med.Chem.
|
