×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.20
Functional Family D-alanine--D-alanine ligase

Enzyme Information

6.3.2.4
D-alanine--D-alanine ligase.
based on mapping to UniProt Q5HEB7
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

UniProtKB Entries (1)

Q5HEB7
DDL_STAAC
Staphylococcus aureus subsp. aureus COL
D-alanine--D-alanine ligase

PDB Structure

PDB 3N8D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9.
Meziane-Cherif, D., Saul, F.A., Moubareck, C., Weber, P., Haouz, A., Courvalin, P., Perichon, B.
J.Bacteriol.
CATH-Gene3D is a Global Biodata Core Resource Learn more...