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1 keywords

CATH Domain 3mqmB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.920 Histone Acetyltransferase; Chain A
Homologous Superfamily 1.20.920.10 Bromodomain-like

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NR48
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9NR48
ASH1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase ASH1L

PDB Structure

PDB 3MQM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos, P., Picaud, S., Mangos, M., Keates, T., Lambert, J.P., Barsyte-Lovejoy, D., Felletar, I., Volkmer, R., Muller, S., Pawson, T., Gingras, A.C., Arrowsmith, C.H., Knapp, S.
Cell(Cambridge,Mass.)
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