CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1000 | HAD superfamily/HAD-like |
Domain Context
CATH Clusters
| Superfamily | HAD superfamily/HAD-like |
| Functional Family | D,D-heptose 1,7-bisphosphate phosphatase |
Enzyme Information
| 3.1.3.82 |
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase.
based on mapping to UniProt Q7WG29
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(2)O = D-glycero-beta- D-manno-heptose 1-phosphate + phosphate.
-!- The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno- heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. -!- In vitro the catalytic efficiency with the beta-anomer is 100-200- fold higher than with the alpha-anomer.
|
UniProtKB Entries (1)
| Q7WG29 |
GMHBB_BORBR
Bordetella bronchiseptica RB50
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
|
PDB Structure
| PDB | 3L8H |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Biochemistry
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