CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Phenylethanolamine N-methyltransferase |
Enzyme Information
| 2.1.1.28 |
Phenylethanolamine N-methyltransferase.
based on mapping to UniProt P11086
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
-!- Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
|
UniProtKB Entries (1)
| P11086 |
PNMT_HUMAN
Homo sapiens
Phenylethanolamine N-methyltransferase
|
PDB Structure
| PDB | 3KR2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
Biochem.J.
|
