CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family |
Enzyme Information
| 3.4.21.88 |
Repressor LexA.
based on mapping to UniProt O33927
Hydrolysis of Ala-|-Gly bond in repressor LexA.
-!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24.
|
UniProtKB Entries (1)
| O33927 |
LEXA_THEMA
Thermotoga maritima MSB8
LexA repressor
|
PDB Structure
| PDB | 3K2Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a LexA protein from Thermotoga maritima
To be Published
|
