CATH Domain 3iecD03

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.10	DNA helicase RuvA subunit, C-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA helicase RuvA subunit, C-terminal domain
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt Q7KZI7 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26	[Tau protein] kinase. based on mapping to UniProt Q7KZI7 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (2)

P55980	CAGA_HELPY Helicobacter pylori 26695 Cytotoxicity-associated immunodominant antigen
Q7KZI7	MARK2_HUMAN Homo sapiens Serine/threonine-protein kinase MARK2

PDB Structure

PDB	3IEC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nesic, D., Miller, M.C., Quinkert, Z.T., Stein, M., Chait, B.T., Stebbins, C.E. Nat.Struct.Mol.Biol.