1 keywords

CATH Domain 3i2iA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1820 alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

3.1.1.84
Cocaine esterase.
based on mapping to UniProt Q9L9D7
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
-!- Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.

UniProtKB Entries (1)

Q9L9D7
COCE_RHOSM
Rhodococcus sp. MB1 'Bresler 1999'
Cocaine esterase

PDB Structure

PDB 3I2I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of thermostabilizing mutations of cocaine esterase.
Narasimhan, D., Nance, M.R., Gao, D., Ko, M.C., Macdonald, J., Tamburi, P., Yoon, D., Landry, D.M., Woods, J.H., Zhan, C.G., Tesmer, J.J., Sunahara, R.K.
Protein Eng.Des.Sel.
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