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1 keywords

CATH Domain 3hpxB01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.3.3.13
2-isopropylmalate synthase.
based on mapping to UniProt P9WQB3
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.

UniProtKB Entries (1)

P9WQB3
LEU1_MYCTU
Mycobacterium tuberculosis H37Rv
2-isopropylmalate synthase

PDB Structure

PDB 3HPX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Huisman, F.H., Koon, N., Bulloch, E.M., Baker, H.M., Baker, E.N., Squire, C.J., Parker, E.J.
Biochemistry
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