CATH Domain 3hc8A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

3.1.4.53

3',5'-cyclic-AMP phosphodiesterase.

based on mapping to UniProt P27815

Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.

-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

O76074

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB	3HC8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. Hughes, R.O., Walker, J.K., Cubbage, J.W., Fobian, Y.M., Rogier, D.J., Heasley, S.E., Blevis-Bal, R.M., Benson, A.G., Owen, D.R., Jacobsen, E.J., Freskos, J.N., Molyneaux, J.M., Brown, D.L., Stallings, W.C., Acker, B.A., Maddux, T.M., Tollefson, M.B., Williams, J.M., Moon, J.B., Mischke, B.V., Rumsey, J.M., Zheng, Y., Macinnes, A., Bond, B.R., Yu, Y. Bioorg.Med.Chem.Lett.

Network disruptions