CATH Domain 3gznD02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.520	Ubiquitin activating enzymes (Uba3). Chain: B, domain 2

Domain Context

CATH Clusters

Superfamily	Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
Functional Family	NEDD8-activating enzyme E1 catalytic subunit

Enzyme Information

6.2.1.-

Acid--thiol ligases.

based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

NEDD8_HUMAN

Homo sapiens

NEDD8

PDB Structure

PDB	3GZN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Brownell, J.E., Sintchak, M.D., Gavin, J.M., Liao, H., Bruzzese, F.J., Bump, N.J., Soucy, T.A., Milhollen, M.A., Yang, X., Burkhardt, A.L., Ma, J., Loke, H.K., Lingaraj, T., Wu, D., Hamman, K.B., Spelman, J.J., Cullis, C.A., Langston, S.P., Vyskocil, S., Sells, T.B., Mallender, W.D., Visiers, I., Li, P., Claiborne, C.F., Rolfe, M., Bolen, J.B., Dick, L.R. Mol.Cell