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1 keywords

CATH Domain 3ghmA03

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.830  

Domain Context

CATH Clusters

Superfamily 2.60.120.830
Functional Family ADAM metallopeptidase with thrombospondin type 1 motif 13

Enzyme Information

3.4.24.87
ADAMTS13 endopeptidase.
based on mapping to UniProt Q76LX8
The enzyme cleaves the von Willebrand factor at bond 842-Tyr-|-Met-843 within the A2 domain.
-!- Belongs to peptidase family M12.

UniProtKB Entries (1)

Q76LX8
ATS13_HUMAN
Homo sapiens
A disintegrin and metalloproteinase with thrombospondin motifs 13

PDB Structure

PDB 3GHM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
Akiyama, M., Takeda, S., Kokame, K., Takagi, J., Miyata, T.
To be Published
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