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1 keywords

CATH Domain 3ewiB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1000 HAD superfamily/HAD-like

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family N-acylneuraminate cytidylyltransferase A

Enzyme Information

2.7.7.43
N-acylneuraminate cytidylyltransferase.
based on mapping to UniProt Q99KK2
CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
-!- Acts on N-acetyl- and N-glycolyl- derivatives.

UniProtKB Entries (1)

Q99KK2
NEUA_MOUSE
Mus musculus
N-acylneuraminate cytidylyltransferase

PDB Structure

PDB 3EWI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.
Oschlies, M., Dickmanns, A., Haselhorst, T., Schaper, W., Stummeyer, K., Tiralongo, J., Weinhold, B., Gerardy-Schahn, R., von Itzstein, M., Ficner, R., Munster-Kuhnel, A.K.
J.Mol.Biol.
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