CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1380 | Neutral endopeptidase; domain 2 |
|
1.10.1380.10 | Neutral endopeptidase , domain2 |
Domain Context
CATH Clusters
| Superfamily | Neutral endopeptidase , domain2 |
| Functional Family | endothelin-converting enzyme 2 isoform X1 |
Enzyme Information
| 3.4.24.71 |
Endothelin-converting enzyme 1.
based on mapping to UniProt P42892
Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.
-!- Phosphoramidon-sensitive. -!- Belongs to peptidase family M13.
|
UniProtKB Entries (1)
| P42892 |
ECE1_HUMAN
Homo sapiens
Endothelin-converting enzyme 1
|
PDB Structure
| PDB | 3DWB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of human endothelin-converting enzyme I complexed with phosphoramidon
J.Mol.Biol.
|
