CATH Domain 3dojA02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	Glyoxylate/succinic semialdehyde reductase 2

Enzyme Information

1.1.1.n11	Succinic semialdehyde reductase. based on mapping to UniProt Q9LSV0 4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
1.1.1.79	Glyoxylate reductase (NADP(+)). based on mapping to UniProt Q9LSV0 Glycolate + NADP(+) = glyoxylate + NADPH. -!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).

UniProtKB Entries (1)

GLYR1_ARATH

Arabidopsis thaliana

Glyoxylate/succinic semialdehyde reductase 1

PDB Structure

PDB	3DOJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cytosolic NADPH-dependent Glyoxylate Reductase from Arabidopsis: Crystal Structure and Kinetic Characterization of Active Site Mutants Hoover, G., Jorgensen, R., Merrill, A.R., Shelp, B.J. To be Published