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1 keywords

CATH Domain 3b6hB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.630 Cytochrome p450
Homologous Superfamily 1.10.630.10 Cytochrome P450

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Prostaglandin I2 (prostacyclin) synthase

Enzyme Information

5.3.99.4
Prostaglandin-I synthase.
based on mapping to UniProt Q16647
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
-!- Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).

UniProtKB Entries (1)

Q16647
PTGIS_HUMAN
Homo sapiens
Prostacyclin synthase

PDB Structure

PDB 3B6H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
Li, Y.-C., Chiang, C.-W., Yeh, H.-C., Hsu, P.-Y., Whitby, F.G., Wang, L.-H., Chan, N.-L.
J.Biol.Chem.
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