CATH Domain 2yk4A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.370	Barnase; Chain D
	3.30.370.20

Domain Context

CATH Clusters

Superfamily	3.30.370.20
Functional Family

Enzyme Information

2.4.99.6

N-acetyllactosaminide alpha-2,3-sialyltransferase.

based on mapping to UniProt P72097

CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D- galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.

-!- The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. -!- The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1. -!- Formerly EC 2.4.99.10.

UniProtKB Entries (1)

P72097

LST_NEIMB

Neisseria meningitidis MC58

N-acetyllactosaminide alpha-2,3-sialyltransferase

PDB Structure

PDB	2YK4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis Lin, L.Y.C., Rakic, B., Chiu, C.P.C., Lameignere, E., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J. J.Biol.Chem.