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1 keywords

CATH Domain 2yk4A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.370 Barnase; Chain D
Homologous Superfamily 3.30.370.20  

Domain Context

CATH Clusters

Superfamily 3.30.370.20
Functional Family

Enzyme Information

2.4.99.6
N-acetyllactosaminide alpha-2,3-sialyltransferase.
based on mapping to UniProt P72097
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D- galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
-!- The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. -!- The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1. -!- Formerly EC 2.4.99.10.

UniProtKB Entries (1)

P72097
LST_NEIMB
Neisseria meningitidis MC58
N-acetyllactosaminide alpha-2,3-sialyltransferase

PDB Structure

PDB 2YK4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis
Lin, L.Y.C., Rakic, B., Chiu, C.P.C., Lameignere, E., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
J.Biol.Chem.
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