CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Collagenase 3 |
Enzyme Information
| 3.4.24.23 |
Matrilysin.
based on mapping to UniProt P09237
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
-!- Similar in specificity to stromelysin, but more active on azocoll. -!- Belongs to peptidase family M10B.
|
UniProtKB Entries (1)
| P09237 |
MMP7_HUMAN
Homo sapiens
Matrilysin
|
PDB Structure
| PDB | 2Y6D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Chemmedchem
|
