CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.20 | Ubiquitin-like (UB roll) |
|
3.10.20.770 |
Domain Context
CATH Clusters
| Superfamily | 3.10.20.770 |
| Functional Family | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
Enzyme Information
| 2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt Q8BTI9
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
|
UniProtKB Entries (1)
| O08908 |
P85B_MOUSE
Mus musculus
Phosphatidylinositol 3-kinase regulatory subunit beta
|
PDB Structure
| PDB | 2Y3A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Mol.Cell
|
