CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1400 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1400 |
| Functional Family | Sirohydrochlorin cobaltochelatase |
Enzyme Information
| 4.99.1.3 |
Sirohydrochlorin cobaltochelatase.
based on mapping to UniProt Q05592
Cobalt-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Co(2+).
-!- This enzyme is a type II chelatase, being either a monomer (CbiX) or a homodimer (CibK) and being ATP-independent. -!- CbiK from Salmonella enterica uses precorrin-2 as the substrate to yield cobalt-precorrin-2. -!- The enzyme contains two histidines at the active site that are thought to be involved in the deprotonation of the tetrapyrrole substrate as well as in metal binding. -!- CbiX from Bacillus megaterium inserts cobalt at the level of sirohydrochlorin (factor-II) rather than precorrin-2.
|
UniProtKB Entries (1)
| Q05592 |
CBIK_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sirohydrochlorin cobaltochelatase
|
PDB Structure
| PDB | 2XWP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA
|
