CATH Domain 2wfdB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.740	Isoleucyl-tRNA Synthetase; domain 2
	3.90.740.10	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

Domain Context

CATH Clusters

Superfamily	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family	Leucine--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.4

Leucine--tRNA ligase.

based on mapping to UniProt Q9P2J5

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

SYLC_HUMAN

Homo sapiens

Leucine--tRNA ligase, cytoplasmic

PDB Structure

PDB	2WFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles. Seiradake, E., Mao, W., Hernandez, V., Baker, S.J., Plattner, J.J., Alley, M.R.K., Cusack, S. J.Mol.Biol.