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1 keywords

CATH Domain 2vfaA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P20035
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.22
Xanthine phosphoribosyltransferase.
based on mapping to UniProt P20035
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.

UniProtKB Entries (2)

P20035
HGXR_PLAFG
Plasmodium falciparum FCR-3/Gambia
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
P00492
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 2VFA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of a Chimera of Human and Plasmodium Falciparum Hypoxanthine Guanine Phosphoribosyltransferases Provides Insights Into Oligomerization.
Gayathri, P., Sujay Subbayya, I.N., Ashok, C.S., Selvi, T.S., Balaram, H., Murthy, M.R.N.
Proteins
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