CATH Domain 2rqbA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.30	RIG-I-like receptor, C-terminal regulatory domain

Domain Context

CATH Clusters

Superfamily	RIG-I-like receptor, C-terminal regulatory domain
Functional Family	Interferon-induced with helicase C domain 1

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt Q9BYX4

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9BYX4

IFIH1_HUMAN

Homo sapiens

Interferon-induced helicase C domain-containing protein 1

PDB Structure

PDB	2RQB
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS Takahasi, K., Kumeta, H., Tsuduki, N., Narita, R., Shigemoto, T., Hirai, R., Yoneyama, M., Horiuchi, M., Ogura, K., Fujita, T., Inagaki, F. J.Biol.Chem.

Network disruptions