CATH Domain 2qtwA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.80	Peptidase S8 propeptide/proteinase inhibitor I9

Domain Context

CATH Clusters

Superfamily	Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family	Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

PCSK9_HUMAN

Homo sapiens

Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB	2QTW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Hampton, E.N., Knuth, M.W., Li, J., Harris, J.L., Lesley, S.A., Spraggon, G. Proc.Natl.Acad.Sci.Usa