CATH Domain 2q1lD02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.770	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
	3.90.770.10	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Superfamily	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family	3-hydroxy-3-methylglutaryl coenzyme A reductase

1.1.1.34

Hydroxymethylglutaryl-CoA reductase (NADPH).

based on mapping to UniProt P04035

(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

HMDH_HUMAN

Homo sapiens

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB	2Q1L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Pfefferkorn, J.A., Song, Y., Sun, K.L., Miller, S.R., Trivedi, B.K., Choi, C., Sorenson, R.J., Bratton, L.D., Unangst, P.C., Larsen, S.D., Poel, T.J., Cheng, X.M., Lee, C., Erasga, N., Auerbach, B., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G., Robertson, A., Olsen, K., Mertz, T., Sekerke, C., Pavlovsky, A., Harris, M.S., Bainbridge, G., Caspers, N., Chen, H., Eberstadt, M. Bioorg.Med.Chem.Lett.