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1 keywords

CATH Domain 2pfrB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.2140 Arylamine N-acetyltransferase fold
Homologous Superfamily 3.30.2140.20  

Domain Context

CATH Clusters

Superfamily 3.30.2140.20
Functional Family Arylamine N-acetyltransferase 1

Enzyme Information

2.3.1.5
Arylamine N-acetyltransferase.
based on mapping to UniProt P11245
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
-!- Wide specificity for aromatic amines, including serotonin; also catalyzes acetyl-transfer between arylamines without CoA.

UniProtKB Entries (1)

P11245
ARY2_HUMAN
Homo sapiens
Arylamine N-acetyltransferase 2

PDB Structure

PDB 2PFR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of Human N-acetyltransferase 2 in complex with CoA
Wu, H., Tempel, W., Dombrovski, L., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Grant, D.M., Plotnikov, A.N., Structural Genomics Consortium (SGC)
to be published
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