CATH Domain 2obcB02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Riboflavin biosynthesis protein RibD

Enzyme Information

1.1.1.193	5-amino-6-(5-phosphoribosylamino)uracil reductase. based on mapping to UniProt P25539 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6- (5-phospho-D-ribosylamino)uracil + NADPH.
3.5.4.26	Diaminohydroxyphosphoribosylaminopyrimidine deaminase. based on mapping to UniProt P25539 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3). -!- The substrate is the product of EC 3.5.4.25.

UniProtKB Entries (1)

RIBD_ECOLI

Escherichia coli K-12

Riboflavin biosynthesis protein RibD

PDB Structure

PDB	2OBC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli: implications for the reductive mechanism. Stenmark, P., Moche, M., Gurmu, D., Nordlund, P. J.Mol.Biol.