CATH Domain 2mscB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	KRAS proto-oncogene, GTPase

Enzyme Information

UniProtKB Entries (1)

A0A024RAV5_HUMAN

Homo sapiens

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b

PDB Structure

PDB	2MSC
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site. Mazhab-Jafari, M.T., Marshall, C.B., Smith, M.J., Gasmi-Seabrook, G.M., Stathopulos, P.B., Inagaki, F., Kay, L.E., Neel, B.G., Ikura, M. Proc.Natl.Acad.Sci.USA