CATH Domain 2mahA00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2000	Frizzled cysteine-rich domain
	1.10.2000.10	Frizzled cysteine-rich domain

Domain Context

CATH Clusters

Superfamily	Frizzled cysteine-rich domain
Functional Family	Blast:Protein smoothened

Enzyme Information

UniProtKB Entries (1)

SMO_DROME

Drosophila melanogaster

Protein smoothened

PDB Structure

PDB	2MAH
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. Rana, R., Carroll, C.E., Lee, H.J., Bao, J., Marada, S., Grace, C.R., Guibao, C.D., Ogden, S.K., Zheng, J.J. Nat Commun