CATH Domain 2ijeS00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.840	Son of Sevenless (SoS) protein; Chain S, domain 2
	1.10.840.10	Ras guanine-nucleotide exchange factors catalytic domain

Domain Context

CATH Clusters

Superfamily	Ras guanine-nucleotide exchange factors catalytic domain
Functional Family	ras-specific guanine nucleotide-releasing factor 2 isoform X1

Enzyme Information

UniProtKB Entries (1)

RGRF1_MOUSE

Mus musculus

Ras-specific guanine nucleotide-releasing factor 1

PDB Structure

PDB	2IJE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A Ras-induced conformational switch in the Ras activator Son of sevenless. Freedman, T.S., Sondermann, H., Friedland, G.D., Kortemme, T., Bar-Sagi, D., Marqusee, S., Kuriyan, J. Proc.Natl.Acad.Sci.Usa