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1 keywords

CATH Domain 2hdhB02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1040 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homologous Superfamily 1.10.1040.10 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family

Enzyme Information

1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q16836
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

Q16836
HCDH_HUMAN
Homo sapiens
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

PDB Structure

PDB 2HDH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.
Barycki, J.J., O'Brien, L.K., Bratt, J.M., Zhang, R., Sanishvili, R., Strauss, A.W., Banaszak, L.J.
Biochemistry
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