CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.270 | Reverse transcriptase/Diguanylate cyclase domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.270 |
| Functional Family | Polymerase (DNA directed) iota |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| Q9UNA4 |
POLI_HUMAN
Homo sapiens
DNA polymerase iota
|
PDB Structure
| PDB | 2FLL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure
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