CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Salicylate/benzoate carboxyl methyltransferase |
Enzyme Information
| 2.1.1.158 |
7-methylxanthosine synthase.
based on mapping to UniProt A4GE69
S-adenosyl-L-methionine + xanthosine = S-adenosyl-L-homocysteine + 7-methylxanthosine.
-!- The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates. -!- The enzyme does not have N(1)- or N(3)- methylation activity. -!- This is the first methylation step in the production of caffeine.
|
UniProtKB Entries (1)
| A4GE69 |
XMT1_COFCA
Coffea canephora
7-methylxanthosine synthase 1
|
PDB Structure
| PDB | 2EG5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of two N-methyltransferases from the caffeine biosynthetic pathway
Plant Physiol.
|
