CATH Domain 2dr0B00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Carboxylic ester hydrolase

Enzyme Information

3.1.1.56	Methylumbelliferyl-acetate deacetylase. based on mapping to UniProt P23141 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate. -!- Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
3.1.1.1	Carboxylesterase. based on mapping to UniProt P23141 A carboxylic ester + H(2)O = an alcohol + a carboxylate. -!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.

UniProtKB Entries (1)

EST1_HUMAN

Homo sapiens

Liver carboxylesterase 1

PDB Structure

PDB	2DR0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 Bencharit, S., Edwards, C.C., Morton, C.L., Howard-Williams, E.L., Kuhn, P., Potter, P.M., Redinbo, M.R. J.Mol.Biol.